Receptor-mediated transferrin endocytosishttp://www-rics.bwh.harvard.edu/sickle/iron_transport.html

• Ferro-transferrin binds to transferrin receptors on the external surface of the cell

• The complex is internalized into an endosome, where the pH is lowered to about 5.5

• Iron separates from the transferrin molecule, moving into the cell cytoplasm

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