The general structure ofthe transferrin receptorhttp://www-rics.bwh.harvard.edu/sickle/iron_transport.html

• The molecule is a transmembrane homodimer linked by disulfide bonds

• An acyl group attached to the cytoplasmic tail of the molecule anchors the assembly to the plasma membrane

• Diferric transferrin binds with higher affinity than monoferric transferrin or apotransferrin

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